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Régine Mydlarski, MD, University of Calgary, Calgary, AB Skin cancer affects nearly 100,000 Canadians per year and is the most common type of cancer worldwide. Yet the molecular mechanisms underlying skin cancer development remain largely unknown. We have recently identified structures within normal and cancerous skin cells, called GW bodies (GWBs). These important structures are involved in a new pathway of genetic control, termed "RNA interference" or “RNAi”. Researchers have used this pathway to develop novel treatment approaches for a variety of cancers. Using innovative technologies, we propose to carry out a comprehensive protein-based study on the GWBs of squamous cell carcinomas (SCCs), a type of non-melanoma skin cancer. By studying the proteins expressed in SCCs, we will: 1) gain insight into the process of skin cancer development; 2) discover tissue markers of disease progression; and 3) identify potential therapeutic targets. Ultimately, we will apply our knowledge toward the development of diagnostic, prognostic and therapeutic tools that are essential for the management of skin cancer patients. Peer-Reviewed Publications Supported by the Canadian Dermatology Foundation Blondin DA, Zhang Z, Shideler KK, Hou H, Fritzler MJ and Mydlarski PR. The prevalence of non-organ specific autoantibodies in patients with pemphigus vulgaris. J Cutan Med Surg Epub 2008, 1-6 (DOI 10.2310/7750.2008.08001). Zee JM, Shideler KK, Eystathioy T, Bruecks AK, Fritzler MJ and Mydlarski PR. GW bodies: cytoplasmic compartments in normal human skin. J Invest Dermatol 128(12):2909-12, 2008. Walsh SRA, Hogg D and Mydlarski PR. Bullous pemphigoid: from bench to bedside. Drugs 65(7): 905-926, 2005. © 2009 |
